Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 13, Issue 12, Pages 1146-1150Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2011.617744
Keywords
marine-derived Streptomyces sp.; bisamide; diketopiperazine; antitumor activity
Funding
- Ministry of Science and Technology, China [2007AA 09Z413]
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A new bisamide N-1-acetyl-N-7-phenylacetyl cadaverine (1) and a series of diketopiperazines including a new diketopiperazine cyclo(2-hydroxy-Pro-R-Leu) (2), together with a new natural product cyclo(4-hydroxy-S-Pro-S-Trp) (3) and two known leucine-based diketopiperazines cyclo(4-hydroxy-R-Pro-S-Leu) (4) and cyclo (S-Pro-R-Leu) (5), were isolated from ethyl acetate extract of a fermentation broth of a marine-derived Streptomyces sp. Their structures were elucidated by the interpretation of spectroscopic analysis. The antitumor activities of compounds 1-3 against HL-60 cell lines were tested by MTT assay.
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