Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 12, Issue 12, Pages 1038-1043Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2010.532490
Keywords
Euphorbiaceae; Euphorbia fischeriana; tigliane diterpenoids; cytotoxic
Funding
- Chinese Academy of Sciences [SIMM0709QN-05]
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Six tigliane-type diterpenoids (1-6) were isolated from the roots of Euphorbia fischeriana. Their structures were elucidated by various spectral analyses. Among them, compounds 1 and 3 were new, and compounds 2, 4, and 5 were naturally obtained for the first time. All compounds were tested against two human cancer cell lines, MDA-MB-231 and HepG2, and one human immortalized cell line, and only compound 6 showed cytotoxicity for MDA-MB-231 cells with an IC50 value of 6.694M.
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