Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 11, Issue 11, Pages 912-917Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020903219923
Keywords
Penicillium griseofulvum; marine fungus; cytotoxicity
Funding
- Ministry of Science and Technology of China [2007AA09Z435]
- National Natural Science Foundation of China [40776098]
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Two new compounds, 4-hydroxyphenethyl methyl succinate (1) and 4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate (2), were isolated from the EtOAc extract of the broth of the marine fungus Penicillium griseofulvum Y19-07. Five known compounds were also obtained in this study. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for their scavenging properties toward the 2,2-diphenyl-1-picrylhydrazyl free radical by spectroscopic assays. Also, in the cytotoxicity assay of the two new compounds against HL-60 and PC-3 prostate cancer cell lines, compound 2 showed potential activity with an IC50 value of 64.5 mu M against human HL-60 cancer cells.
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