Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 11, Issue 11, Pages 929-932Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020903302315
Keywords
macagigantin; farnesylated flavonol; Macaranga gigantea; Euphorbiaceae; cytotoxicity; P-388 cells
Funding
- office of the Ministry of National Education, Republic of Indonesia [VII 2009]
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A new farnesylated flavonol derivative, macagigantin (1), together with two known flavonoids, glyasperin A (2) and apigenin (3), had been isolated from the acetone extract of the leaves of Macaranga gigantea. The structure of the new compound was elucidated as 6-farnesylkaempferol based on its spectroscopic data, including UV, IR, 1D and 2D NMR, and HR-EI-MS spectra. Compounds 1-3 were evaluated for their cytotoxic properties against P-388 cells, their IC50 values being 11.3, 6.0, and 5.1 mu M, respectively.
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