Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 10, Issue 3, Pages 252-255Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020701605075
Keywords
Salvia yunnanensis; Labiatae; salvianolic acid N; anti-HIV activity
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A new polyphenol, designated as salvianolic acid N, was isolated from the aqueous extracts of the roots of Salvia yunnanensis. Its chemical structure was elucidated as 3-(3,4-dihydroxylphenyl)-2-{(E)-3-(1,8,9-trihydroxyl-dibenzo[b,f]oxpin-3-yl)acryloxloxy}propanoic acid (1) on the basis of NMR and MS spectral analyses. The new polyphenol inhibited both HIV-1 IN in vitro and also reduced HIV-1 p24 antigen in MT-4 cell lines.
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