Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 10, Issue 6, Pages 485-490Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020701833479
Keywords
Humulus lupulus; cannabinaceae; hops; prenylchalcones; cytotoxicity
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Two new prenylchalcones, xanthohumol C and D, together with two known prenylchalcone derivatives, xanthohumol (1) and 5 ''-(2 ''-hydroxyisopropyl)-dihydrofurano-[2 '',3 ''-b]-4,4'-dihydroxy-6'-methoxy-chalcone (4) were isolated and identified from the hops of Humulus lupulus L. The structures of xanhohumol C and D were elucidated as 5 ''-hydroxy-6 '',6 ''-dimethyl-dihydropyrano-[2 '',3 ''-b]- 4,4'-dihydroxy-6'-methoxy-chalcone (2) and 5 ''-hydroxy-'' 6,6 ''-dimethyl-dihydropyrano-[2 '',3 ''-b]-4',6'-dimethoxy-4-hydroxy-chalcone (3) on the basis of HRFAB-MS, 1D and 2D NMR (HMQC, HMBC) spectroscopic data. Among the new prenylchalcones, compound 2 showed marginal cytotoxic activity against human stomach carcinoma BGC-823 and human hepatic carcinoma HepG2 cells.
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