Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 10, Issue 1, Pages 17-24Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020701273627
Keywords
Andrographis paniculata; Acanthaceae; andropaniculosin A; andropaniculoside A; antiplatelet; aggregation; vasorelaxing effect
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Two new flavones, designated as andropaniculosin A (1) and andropaniculoside A (2), and 30 known compounds were isolated as a result of detailed chemical examination on the whole plants of Andrographis paniculata. Their structures have been elucidated mainly by 1D and 2D NMR, and MS spectroscopic methods. Among them, four flavonoids showed potent inhibition of collagen, arachidonic acid, thrombin, and platelet activation factor induced platelet aggregation. Furthermore, a diterpenoid demonstrated moderate vasorelaxing effect in isolated rat thoracic aorta.
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