Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 59, Issue 8, Pages 5061-5064Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00921-15
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- National Institutes of Health. R.A.C. - Dominican University of California [AI1R01AI075045, U19AI089674, D43TW007375, T37MD003407]
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We evaluated markers of artemisinin resistance in Plasmodium falciparum isolated in Kampala in 2014. By standard in vitro assays, all isolates were highly sensitive to dihydroartemisinin (DHA). By the ring-stage survival assay, after a 6-h DHA pulse, parasitemia was undetectable in 40 of 43 cultures at 72 h. Two of 53 isolates had nonsynonymous K13-propeller gene polymorphisms but did not have the mutations associated with resistance in Asia. Thus, we did not see evidence for artemisinin resistance in Uganda.
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