Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 60, Issue 1, Pages 646-649Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01886-15
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Funding
- Swiss National Science Foundation (SNSF) [32003B_153377]
- Ministero della Salute (Ministry of Health, Italy) [CCM 2014]
- Italian Flagship InterOmics project - MIUR [PB.P05]
- Italian Council of National Research (CNR)
- Swiss National Science Foundation (SNF) [32003B_153377] Funding Source: Swiss National Science Foundation (SNF)
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A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla(KPC) genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla(KPC-3) gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla(KPC-3)::Tn4401a caused by intramolecular transposition events were detected in the plasmid.
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