Journal
NATURE NEUROSCIENCE
Volume 18, Issue 2, Pages 170-181Publisher
NATURE PORTFOLIO
DOI: 10.1038/nn.3917
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Funding
- Wellcome Trust [095668]
- Engineering and Physical Sciences Research Council [1005102, K015141]
- Simons Foundation
- US National Institutes of Health [NS061963, NS087479, DC013272, EB017695]
- Whitehall Foundation
- EPSRC [EP/I005102/1, EP/I005102/2, EP/K015141/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I005102/2, EP/I005102/1, EP/K015141/1] Funding Source: researchfish
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Similarities in neocortical circuit organization across areas and species suggest a common strategy to process diverse types of information, including sensation from diverse modalities, motor control and higher cognitive processes. Cortical neurons belong to a small number of main classes. The properties of these classes, including their local and long-range connectivity, developmental history, gene expression, intrinsic physiology and in vivo activity patterns, are remarkably similar across areas. Each class contains subclasses; for a rapidly growing number of these, conserved patterns of input and output connections are also becoming evident. The ensemble of circuit connections constitutes a basic circuit pattern that appears to be repeated across neocortical areas, with area- and species-specific modifications. Such 'serially homologous' organization may adapt individual neocortical regions to the type of information each must process.
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