Journal
JOURNAL OF APPLIED TOXICOLOGY
Volume 32, Issue 6, Pages 436-445Publisher
WILEY
DOI: 10.1002/jat.1775
Keywords
Aluminium oxide nanomaterials; acute oral toxicity; oxidative stress; antioxidant enzymes; histopathology; Wistar rat
Categories
Funding
- Department of Biotechnology (DBT), New Delhi
Ask authors/readers for more resources
This study investigated the oxidative stress induced after acute oral treatment with 500, 1000 and 2000?mg kg-1 doses of Al2O3-30 and -40?nm and bulk Al2O3 in Wistar rats. Both the nanomaterials induced significant oxidative stress in a dose-dependent manner in comparison to the bulk. There was no significant difference between the two nanomaterials. However, the effect decreased with increase with time after treatment. The histopathological examination showed lesions only in liver with Al2O3 nanomaterials at 2000?mg kg-1. Copyright (C) 2011 John Wiley & Sons, Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available