Journal
NATURE NEUROSCIENCE
Volume 18, Issue 9, Pages 1265-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4084
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Funding
- US National Institutes of Health [NIH/NIMH MH078064, NIH/NINDS NS061963, NS087479]
- Ken and Ruth Davee Award for Innovative Investigations in Mood Disorders
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Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To better understand the mechanisms underlying state-dependent fear, we used a mouse model of contextual fear conditioning. We found that heightened activity of hippocampal extrasynaptic GABA(A) receptors, believed to impair fear and memory, actually enabled their state-dependent encoding and retrieval. This effect required protein kinase C-beta II and was influenced by miR-33, a microRNA that regulates several GABA-related proteins. In the extended hippocampal circuit, extrasynaptic GABAA receptors promoted subcortical, but impaired cortical, activation during memory encoding of context fear. Moreover, suppression of retrosplenial cortical activity, which normally impairs retrieval, had an enhancing effect on the retrieval of state-dependent fear. These mechanisms can serve as treatment targets for managing access to state-dependent memories of stressful experiences.
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