Journal
JOURNAL OF APPLIED TOXICOLOGY
Volume 31, Issue 5, Pages 439-445Publisher
WILEY
DOI: 10.1002/jat.1611
Keywords
nano-CuO; voltage-gated sodium current; hippocampus; reactive oxygen species
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Funding
- National Natural Science Foundation of China [31070890, 31000509]
- UK Royal Academy of Engineering [5502]
- EPSRC [EP/D07942X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D07942X/1] Funding Source: researchfish
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The aim of this study was to investigate the effects of nano-CuO on voltage-gated sodium current (I-Na) in hippocampal CA1 neurons. The results suggested that nano-CuO inhibited amplitudes of I-Na currents and prolonged peak rise time of action potential (AP). The responses to nano-CuO were inhibited by reactive oxygen species (ROS) scavenger. However, the G-proteins inhibitor did not block the effects of nano-CuO. The effects of nano-CuO were mediated through activation of ROS-I-Na-AP signaling cascades and independent from G-proteins pathway. Copyright (c) 2011 John Wiley & Sons, Ltd.
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