Journal
NATURE NEUROSCIENCE
Volume 18, Issue 3, Pages 376-378Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3923
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Funding
- Paris School of Neuroscience Network (ENP)
- Agence Nationale de la Recherche [ANR-12-bsv4-0022-01]
- Fyssen Foundation
- French Ministry of Science (ESR)
- INSERM Atip-Avenir
- ERC [335333]
- European Research Council (ERC) [335333] Funding Source: European Research Council (ERC)
- Agence Nationale de la Recherche (ANR) [ANR-12-BSV4-0022] Funding Source: Agence Nationale de la Recherche (ANR)
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Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K+ currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.
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