Journal
JOURNAL OF APPLIED TOXICOLOGY
Volume 30, Issue 3, Pages 212-217Publisher
WILEY
DOI: 10.1002/jat.1486
Keywords
gold nanoparticles; uptake; toxicity; geometry; protein binding; adsorptive endocytosis
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Funding
- NIH [R01DE19050]
- Utah Science Technology and Research (USTAR) Initiative
- Division Of Earth Sciences
- Directorate For Geosciences [0923495] Funding Source: National Science Foundation
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Using a series of gold nanoparticles with incremental increase in dimensions but varying geometries (spherical vs rods) we have evaluated the influence of shape, size, surface properties and concentration on cellular uptake, adsorption of proteins and toxicity in a human prostate cancer cell line (PC-3). In the range of 30-90 nm diameter studied, spherical particles of SO nm in diameter without polyethylene glycol (PEG) had the highest uptake. Surface attachment of PEG reduced cellular uptake. PEGylated gold nanorods had a net positive charge compared with their spherical counterparts and particle geometry influenced cellular uptake. In the absence of serum proteins the uptake of plain spherical GNPs increased. These studies pave the way for the tailoring of gold nanoparticles for targeted tumor therapy applications. Copyright (C) 2009 John Wiley & Sons, Ltd.
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