Journal
NATURE NEUROSCIENCE
Volume 18, Issue 11, Pages 1556-1558Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4126
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Funding
- US National Institutes of Health [R01 AG036836, R01 AG048015, R01 AG043617, P01 AG036694, P30 AG10161, R01 AG15819, R01 AG17917, U01 AG46152]
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We used a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. The NME8 locus influenced PTK2B and the CD33 risk allele led to greater TREM2 expression. There was also a decreased TREM1/TREM2 ratio with a TREM1 risk allele, decreased TREM2 expression with CD33 suppression and elevated cortical TREM2 mRNA expression with amyloid pathology.
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