Journal
NATURE NEUROSCIENCE
Volume 18, Issue 7, Pages 953-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4040
Keywords
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Categories
Funding
- Innovative Medicines Initiative [115008]
- European Union [GA 286213]
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley
- NHS Foundation Trust
- King's College London
- Netherlands Organisation for Scientific Research NWO Investments [175.010.2005.011, 911-03-012]
- Research Institute for Diseases in the Elderly [014-93-015, RIDE2]
- Netherlands Genomics Initiative (NGI)/Netherlands Consortium for Healthy Aging (NCHA) [050-060-810]
- Erasmus Medical Center
- Erasmus University, Rotterdam
- Netherlands Organization for the Health Research and Development (ZonMw)
- Research Institute for Diseases in the Elderly (RIDE)
- Ministry of Education, Culture, and Science
- Ministry for Health, Welfare, and Sports
- European Commission (DG XII)
- Municipality of Rotterdam
- Netherlands Organization for Scientific Research (NWO)
- MagW/ZonMW
- BBMRI-NL [184.021.007]
- VU University Institute for Health and Care Research (EMGO+)
- Neuroscience Campus Amsterdam
- European Science Council (ERC) Genetics of Mental Illness [230374]
- Avera Institute for Human Genetics and US National Institute of Mental Health [1RC2MH089951-01, 1RC2 MH089995]
- Ragnar Soderberg Foundation [E9/11]
- Swedish Research Council [421-2013-1061]
- Jan Wallander and Tom Hedelius Foundation [P2012-0002:1]
- Sven and Dagmar Salen Foundation
- Bank of Sweden Tercentenary Foundation [M11-0451:1]
- Karolinska Institutet
- Netherlands Scientific Organization [NWO 480-05-003]
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We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 x 10(-6) and 3.8 x 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.
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