Journal
NATURE NEUROSCIENCE
Volume 18, Issue 4, Pages 490-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3963
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Funding
- German Research foundation (DFG) [SFB 870, SPP 1392, Go 640/11-1]
- Munich Cluster for Systems Neurology [EXC 1010 SyNergy]
- Helmholtz Foundation by the ICEMED Alliance
- European Research Council by an ERC Advanced Grant
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We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.
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