4.7 Article

A positive-negative mode of population covariation links brain connectivity, demographics and behavior

Journal

NATURE NEUROSCIENCE
Volume 18, Issue 11, Pages 1565-1567

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4125

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Funding

  1. US National Institutes of Health [1U54MH091657, P30-NS057091, P41-RR08079/EB015894, F30-MH097312]
  2. Wellcome Trust [098369/Z/12/Z, 091509/Z/10/Z]
  3. Engineering and Physical Sciences Research Council [EP/J005444/1] Funding Source: researchfish
  4. Wellcome Trust [100309/A/12/Z, 104765/Z/14/Z] Funding Source: researchfish
  5. EPSRC [EP/J005444/1] Funding Source: UKRI

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We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.

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