Journal
NATURE NANOTECHNOLOGY
Volume 11, Issue 2, Pages 184-190Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NNANO.2015.259
Keywords
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Funding
- National Institutes of Health [R01-GM097399]
- Alfred P. Sloan Research Fellowship
- Camille-Dreyfus Teacher-Scholar Award
- National Science Foundation (NSF) CAREER Award [1350829]
- ARCS Foundation
- NSF [CMMI-1250235]
- Emory University
- Emory University Integrated Cellular Imaging Microscopy Core
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1250235] Funding Source: National Science Foundation
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DNA-based machines that walk by converting chemical energy into controlled motion could be of use in applications such as next-generation sensors, drug-delivery platforms and biological computing. Despite their exquisite programmability, DNA-based walkers are challenging to work with because of their low fidelity and slow rates (similar to 1 nm min(-1)). Here we report DNA-based machines that roll rather than walk, and consequently have a maximum speed and processivity that is three orders of magnitude greater than the maximum for conventional DNA motors. The motors are made from DNA coated spherical particles that hybridize to a surface modified with complementary RNA; the motion is achieved through the addition of RNase H, which selectively hydrolyses the hybridized RNA. The spherical motors can move in a self avoiding manner, and anisotropic particles, such as dimerized or rod-shaped particles, can travel linearly without a track or external force. We also show that the motors can be used to detect single nucleotide polymorphism by measuring particle displacement using a smartphone camera.
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