Journal
NATURE METHODS
Volume 13, Issue 2, Pages 139-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.3690
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Funding
- German Research Foundation within in the priority program SPP 1384 [DFG EL 246/4-1/-2]
- European Union EU-FP7-MitoSys [241548]
- European Molecular Biology Laboratory
- EMBL Interdisciplinary Postdoc Programme (EIPOD) under Marie Curie Actions COFUND
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Despite its importance for understanding human infertility and congenital diseases, early mammalian development has remained inaccessible to in toto imaging. We developed an inverted light-sheet microscope that enabled us to image mouse embryos from zygote to blastocyst, computationally track all cells and reconstruct a complete lineage tree of mouse pre-implantation development. We used this unique data set to show that the first cell fate specification occurs at the 16-cell stage.
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