Journal
NATURE METHODS
Volume 12, Issue 4, Pages 307-318Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.3324
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Funding
- US National Institute of General Medical Sciences Protein Structure Initiative at the Joint Center for Structural Genomics [U54GM094586]
- SLAC National Accelerator Laboratory LDRD (Laboratory Directed Research and Development) [SLAC-LDRD-0014-13-2]
- US National Institutes of Health [OD009180, GM110580]
- US National Science Foundation [STC-1231306]
- Kinship Foundation Searle Scholar Program
- Pew Charitable Trusts Scholars Program
- David and Lucile Packard Foundation Fellowship
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Biomolecules adopt a dynamic ensemble of conformations, each with the potential to interact with binding partners or perform the chemical reactions required for a multitude of cellular functions. Recent advances in X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy and other techniques are helping us realize the dream of seeing-in atomic detail-how different parts of biomolecules shift between functional substates using concerted motions. Integrative structural biology has advanced our understanding of the formation of large macromolecular complexes and how their components interact in assemblies by leveraging data from many low-resolution methods. Here, we review the growing opportunities for integrative, dynamic structural biology at the atomic scale, contending there is increasing synergistic potential between X-ray crystallography, NMR and computer simulations to reveal a structural basis for protein conformational dynamics at high resolution.
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