Journal
NATURE METHODS
Volume 12, Issue 6, Pages 519-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.3370
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Funding
- UK Wellcome Trust
- Belgian Research Foundation Flanders (FWO)
- University of Leuven (KU Leuven, Belgium) [FWO-G.0687.12]
- University of Leuven (KU Leuven, Belgium) (KU Leuven SymBioSys) [PFV/10/016]
- FWO scholarship [FWO-1.1.H28.12]
- UK Medical Research Council
- EU Seventh Framework Programme (FP7) [262055]
- UK Mary Gray Studentship from St. John's College, Cambridge, UK
- New Zealand Woolf-Fisher Trust
- UK Wellcome Trust Senior Investigator award
- Wellcome Trust Sanger Institute Clinical Ph.D. Fellowship (UK)
- University of Oxford Nuffield Department of Medicine Prize Studentship, UK
- BBSRC [BBS/E/T/000PR5885, BBS/E/T/000PR6193] Funding Source: UKRI
- MRC [MR/L023784/1, MC_UU_12021/1, MC_U137761446, MR/L023784/2] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/T/000PR6193, BBS/E/T/000PR5885] Funding Source: researchfish
- Medical Research Council [MC_U137761446, MC_UU_12021/1] Funding Source: researchfish
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The simultaneous sequencing of a single cell's genome and transcriptome offers a powerful means to dissect genetic variation and its effect on gene expression. Here we describe G&T-seq, a method for separating and sequencing genomic DNA and full-length mRNA from single cells. By applying G&T-seq to over 220 single cells from mice and humans, we discovered cellular properties that could not be inferred from DNA or RNA sequencing alone.
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