Journal
JOURNAL OF APPLIED POLYMER SCIENCE
Volume 131, Issue 21, Pages -Publisher
WILEY-BLACKWELL
DOI: 10.1002/app.41034
Keywords
biomaterials; drug delivery systems; self-assembly
Categories
Funding
- National Natural Science Foundation of China [50903039, 81101151]
- Research Fund for the excellent doctorial dissertation of Guangdong Province [sybzzxm201034]
- Fundamental Research Funds for the Central Universities
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Chitosan-graft-beta-cyclodextrin (CS-g-beta-CD) copolymer was synthesized by conjugating beta-cyclodextrins to chitosan molecules through click chemistry. The copolymer structure was characterized by Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR). CS-g-beta-CD/CMC nanoparticles were prepared by a polyelectrolyte complexation process in aqueous solution between CS-g-beta-CD copolymer and carboxymethyl chitosan (CMC), which was used to load anticancer drug (Doxorubicin hydrochloride, DOX center dot HCl) with hydrophobic group. The particle size, surface charge, zeta potential, and morphology of the nanoparticles were characterized with dynamic light scattering. The drug loading efficiency and in vitro release of DOX center dot HCl of the nanoparticles were measured by ultraviolet spectrophotometer. The results demonstrated that the size, surface charge and drug loading efficiency of the nanoparticles could be modulated by the fabrication conditions. The drug loading efficiency of CS-g-beta-CD/CMC nanoparticles was improved from 52.7% to 88.1% because of the presence of beta-CD moieties with hydrophobic cavities, which can form inclusion complexes with the drug molecules. The in vitro release results showed that the CS-g-beta-CD/CMC nanoparticles released DOX center dot HCl in a controlled manner, importantly overcoming the initial burst effect. These nanoparticles possess much potential to be developed as anticancer drug delivery systems, especially those drugs with hydrophobic group. (C) 2014 Wiley Periodicals, Inc.
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