Journal
JOURNAL OF APPLIED POLYMER SCIENCE
Volume 131, Issue 23, Pages -Publisher
WILEY
DOI: 10.1002/app.41138
Keywords
biomaterials; biomedical applications; crosslinking; gels; irradiation
Categories
Funding
- 90th Anniversary of Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund)
- Integrated Innovation Academic Center IIAC, Chulalongkorn University Centenary Academic Development Project, Chulalongkorn University, Thailand [RES_01_54_63]
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An antibacterial hydrogel wound dressing was successfully synthesized by the gamma irradiation method. A gelatin solution was mixed with a poly(vinyl alcohol) (PVA) solution of similar concentrations at different weight ratios of 100 : 0, 80 : 20, and 60 : 40 w/w, and irradiated at 30, 40, or 50 kGy. The testing of physical properties showed that the addition of PVA could improve both durability and mechanical integrity. The 60 : 40 hydrogels irradiated at 30 kGy were optimal, and chosen to add silver nitrate at 0.25, 0.50, 0.75, or 1.00 wt % (based on the solid content) to improve the antibacterial properties. After gamma irradiation, silver nanoparticles (AgNPs) were formed. The AgNP/gelatin/PVA hydrogels were characterized for physical properties, cytotoxicity, and antibacterial activity. The AgNP/gelatin/PVA hydrogels could be used as antibacterial wound dressings because they exhibited appropriate physical properties, noncytotoxicity, and could inhibit the growth of tested bacteria. (C) 2014 Wiley Periodicals, Inc.
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