Journal
NATURE METHODS
Volume 12, Issue 9, Pages 873-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/NMETH.3482
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Funding
- Ecole Normale Superieure de Lyon
- grant from Agence Nationale de la Recherche, Paris
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Innovative imaging methods help to investigate the complex relationship between brain activity and behavior in freely moving animals. Functional ultrasound (fUSUS) is an imaging modality suitable for recording cerebral blood volume (CBV) dynamics in the whole brain but has so far been used only in head-fixed and anesthetized rodents. We designed a fUSUS device for tethered brain imaging in freely moving rats based on a miniaturized ultrasound probe and a custom-made ultrasound scanner. We monitored CBV changes in rats during various behavioral states such as quiet rest, after whisker or visual stimulations, and in a food-reinforced operant task. We show that fUSUS imaging in freely moving rats could efficiently decode brain activity in real time.
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