Journal
NATURE METHODS
Volume 12, Issue 8, Pages 743-U69Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.3466
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Funding
- Cabinet Office of the Government of Japan [LS013]
- Uehara Memorial Foundation
- Japan Society for the Promotion of Science (JSPS) [26440091, 15H01635]
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We have developed a multitarget super-resolution microscopy technique called image reconstruction by integrating exchangeable single-molecule localization (IRIS). IRIS uses protein fragment-based probes that directly associate with and dissociate from their targets over durations on the order of tens of milliseconds. By integrating single-molecule localization and sequential labeling, IRIS enables unprecedented labeling density along multiple cellular structures. IRIS can be used to discern the area-specific proximity between cytoskeletal components and focal adhesions within a single cell.
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