Journal
NATURE METHODS
Volume 12, Issue 3, Pages 195-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.3261
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Funding
- Canada Research Chairs
- Alberta Glycomics Centre
- Canadian Institutes of Health Research [NHG 99085, MOP 123514, MOP 119425]
- Natural Sciences and Engineering Research Council of Canada
- Alberta Ingenuity PhD Scholarships
- National Science Foundation of China Major Research Grant [91132718]
- Beijing Natural Science Foundation [7142085]
- US National Institutes of Health [DP1 CA174423, 5R44NS082222]
- US National Science Foundation Small Business Innovation Research (SBIR) [1248138]
- Montana SBIR matching funds [13-50 RCSBIR-003]
- Directorate For Engineering
- Div Of Industrial Innovation & Partnersh [1248138] Funding Source: National Science Foundation
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We have developed a versatile new class of genetically encoded fluorescent biosensor based on reversible exchange of the heterodimeric partners of green and red dimerization-dependent fluorescent proteins. We demonstrate the use of this strategy to construct both intermolecular and intramolecular ratiometric biosensors for qualitative imaging of caspase activity, Ca2+ concentration dynamics and other second-messenger signaling activities.
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