Journal
JOURNAL OF APPLIED POLYMER SCIENCE
Volume 126, Issue -, Pages E70-E78Publisher
WILEY
DOI: 10.1002/app.36471
Keywords
cellulose acetate; electrospinning; biofibers; membranes; nanotechnology
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Funding
- FAPESP (The Sao Paulo State Research Foundation)
- CNPq (The National Research Council)
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The electrospinning of cellulose acetate (CA) was investigated to develop biodegradable nanostructured membranes for the controlled release of drugs used to treat skin wounds. CA nanofibers were successfully prepared via the electrospinning in the four mixed solvents acetic acid : water; acetone : water; DMAc : acetone; DMAc : acetone : water. Design of experiments (DOE) was applied to see what combinations of parameters could affect the production of electrospun microfibers and nanofibers to optimize the process. The results of this work indicated that both the processing parameters and the solvent mixtures were responsible for the fiber diameter and nanostructure membrane appearance. The optimized condition for each solvent mixture was obtained and compared with each one of the others. The best conditions achieved were dimethylacetamida (DMAc) : acetone with 17% of CA, which provided homogeneous and free bead fibers with an average diameter of 295 nm. (c) 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
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