Journal
NATURE MEDICINE
Volume 21, Issue 4, Pages 314-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3812
Keywords
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Funding
- Swedish Strategic Foundation
- EU Sixth-and Seventh-Framework Programs [MEST-CT-2004-8475]
- Swedish Research Council [VR/2012-2014/521-2011-3377, VR/2011-2018/14251]
- Soderberg Foundation
- Swedish governmental ALF grants
- Karolinska Institutet
- Swedish Academy of Sciences, Swedish governmental ALF grants
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Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.
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