Journal
NATURE MEDICINE
Volume 21, Issue 2, Pages 140-149Publisher
NATURE PORTFOLIO
DOI: 10.1038/nm.3778
Keywords
-
Funding
- German Research Foundation (Programm Klinische Studien)
- Alfried Krupp von Bohlen und Halbach-Stiftung
- German Research Foundation [WO 552/9-1, WO 552/10-1]
Ask authors/readers for more resources
Paracrine-acting proteins are emerging as a central mechanism by which bone marrow cell based therapies improve tissue repair and heart function after myocardial infarction (MI). We carried out a bioinformatic secretome analysis in bone marrow cells from patients with acute MI to identify novel secreted proteins with therapeutic potential. Functional screens revealed a secreted protein encoded by an open reading frame on chromosome 19 (C19orf10) that promotes cardiac myocyte survival and angiogenesis. We show that bone marrow derived monocytes and macrophages produce this protein endogenously to protect and repair the heart after MI, and we named it myeloid-derived growth factor (MYDGF). Whereas Mydgf-deficient mice develop larger infarct scars and more severe contractile dysfunction compared to wild-type mice, treatment with recombinant Mydgf reduces scar size and contractile dysfunction after MI. This study is the first to assign a biological function to MYDGF, and it may serve as a prototypical example for the development of protein-based therapies for ischemic tissue repair.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available