Journal
NATURE MATERIALS
Volume 15, Issue 2, Pages 235-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMAT4476
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Funding
- Office of Science (BER), US Department of Energy [DE-SC0008397]
- NCI Cancer Center Nano technology Excellence Grant (CONE-TR) [U54 CA119367]
- Calhrain Program, a NeurotechnoliDgy Program of California [CA151459]
- National Natural Science Foundation of China [81573383, 81373254, 21390402]
- NSFHP [2014CFB704]
- International S&T Cooperation Program of China [2015DFA30440, 2014DFB30020]
- National Science and Technology Major Project of the Ministry or Science and Technology of China [2012ZX10004801-003-011]
- Key Project of Chinese Ministry of Education [313040]
- Ministry Of Education of China [5052012306001]
- Fundamental Research Funds for the Central Universities
- Innovation Seed Fund of Wuhan University School of Medicine
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Fluorescent imaging of biological systems in the second near-infrared window (NIR-II) can probe tissue at centimetre depths and achieve micrometre-scale resolution at depths of millimetres. Unfortunately, all current NIR-II fluorophores are excreted slowly and are largely retained within the reticuloendothelial system, making clinical translation nearly impossible. Here, we report a rapidly excreted NIR-II fluorophore (similar to 90% excreted through the kidneys within 24 h) based on a synthetic 970-Da organic molecule (CH1055). The fluorophore outperformed indocyanine green (ICG)-a clinically approved NIR-I dye-in resolving mouse lymphatic vasculature and sentinel lymphatic mapping near a tumour. High levels of uptake of PEGylated-CH1055 dye were observed in brain tumours in mice, suggesting that the dye was detected at a depth of similar to 4 mm. The CH1055 dye also allowed targeted molecular imaging of tumours in vivo when conjugated with anti-EGFR Affibody. Moreover, a superior tumour-to-background signal ratio allowed precise image-guided tumour-removal surgery.
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