Journal
JOURNAL OF APPLIED POLYMER SCIENCE
Volume 120, Issue 4, Pages 2448-2458Publisher
WILEY
DOI: 10.1002/app.33459
Keywords
dextran; 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine; copolymeric nanoparticles; doxorubicin; drug delivery
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Funding
- Chinese Academy of Sciences [KJCX2-YW-M02]
- State Key Development Program for Basic Research of China (973) [2009CB930200, 2010 CB934004]
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In this work, a novel biodegradable amphiphilic copolymer based on dextran and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) was successfully prepared. The amphiphilic copolymer may self-assemble into polymeric micelles in an aqueous solution. Fluorescence spectroscopy, dynamic light scattering (DLS), and a transmission electron microscope (TEM) method confirmed the formation of copolymeric micelles. To estimate the feasibility as novel drug carriers, doxorubicin (DOX) was incorporated into polymeric nanoparticles. The DOX-loaded nanoparticles exhibited greater antitumor effect than free DOX for HeLa celles, suggesting that the dextran/DPPE nanoparticles have great potential as a tumor targeting drug carrier. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 120: 2448-2458, 2011
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