Journal
NATURE IMMUNOLOGY
Volume 16, Issue 1, Pages 18-26Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3056
Keywords
-
Categories
Funding
- Asthma UK [S06/001] Funding Source: researchfish
- Medical Research Council [MC_G1001212, G0902266, G1000758] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10150] Funding Source: researchfish
- Medical Research Council [G1000758, G0902266, MC_G1001212] Funding Source: Medline
- MRC [MC_G1001212, G0902266] Funding Source: UKRI
Ask authors/readers for more resources
Respiratory viruses are frequent causes of repeated common colds, bronchitis and pneumonia, which often occur unpredictably as epidemics and pandemics. Despite those decimating effects on health and decades of intensive research, treatments remain largely supportive. The only commonly available vaccines are against influenza virus, and even these need improvement. The lung shares some features with other mucosal sites, but preservation of its especially delicate anatomical structures necessitates a fine balance of pro- and anti-inflammatory responses; well-timed, appropriately placed and tightly regulated T cell and B cell responses are essential for protection from infection and limitation of symptoms, whereas poorly regulated inflammation contributes to tissue damage and disease. Recent advances in understanding adaptive immunity should facilitate vaccine development and reduce the global effect of respiratory viruses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available