Journal
NATURE IMMUNOLOGY
Volume 16, Issue 1, Pages 27-35Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3045
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Funding
- US National Institutes of Health [HL110964, HL122642, HL110967, DK093784]
- Burroughs Wellcome Fund
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U01HL122642, U01HL110967, U01HL110964] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK092306, K08DK093784] Funding Source: NIH RePORTER
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The epithelial surfaces of the lungs are in direct contact with the environment and are subjected to dynamic physical forces as airway tubes and alveoli are stretched and compressed during ventilation. Mucociliary clearance in conducting airways, reduction of surface tension in the alveoli, and maintenance of near sterility have been accommodated by the evolution of a multi-tiered innate host-defense system. The biophysical nature of pulmonary host defenses are integrated with the ability of respiratory epithelial cells to respond to and 'instruct' the professional immune system to protect the lungs from infection and injury.
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