Journal
NATURE IMMUNOLOGY
Volume 16, Issue 6, Pages 663-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3154
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Funding
- National Health and Medical Research Council (NHMRC) of Australia (NHMRC IRIISS) [361646]
- National Health and Medical Research Council (NHMRC) of Australia [575500, 1054925, 1054618, 1023454]
- Multiple Myeloma Research Foundation
- Australian Research Council (ARC)
- Victorian State Government through an Operational Infrastructure Support grant
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When B cells encounter an antigen, they alter their physiological state and anatomical localization and initiate a differentiation process that ultimately produces antibody-secreting cells (ASCs). We have defined the transcriptomes of many mature B cell populations and stages of plasma cell differentiation in mice. We provide a molecular signature of ASCs that highlights the stark transcriptional divide between B cells and plasma cells and enables the demarcation of ASCs on the basis of location and maturity. Changes in gene expression correlated with cell-division history and the acquisition of permissive histone modifications, and they included many regulators that had not been previously implicated in B cell differentiation. These findings both highlight and expand the core program that guides B cell terminal differentiation and the production of antibodies.
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