Journal
NATURE IMMUNOLOGY
Volume 16, Issue 5, Pages 448-457Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3153
Keywords
-
Categories
Funding
- Versus Arthritis [19796, 20770] Funding Source: researchfish
- Arthritis Research UK [19796, 20770] Funding Source: Medline
- Versus Arthritis [19796, 20770] Funding Source: Medline
Ask authors/readers for more resources
Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not of the immune system and often displays hormone-like characteristics that affect homeostatic processes. IL-6 has context-dependent pro-and anti-inflammatory properties and is now regarded as a prominent target for clinical intervention. However, the signaling cassette that controls the activity of IL-6 is complicated, and distinct intervention strategies can inhibit this pathway. Clinical experience with antagonists of IL-6 has raised new questions about how and when to block this cytokine to improve disease outcome and patient wellbeing. Here we discuss the effect of IL-6 on innate and adaptive immunity and the possible advantages of various antagonists of IL-6 and consider how the immunobiology of IL-6 may inform clinical decisions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available