Journal
NATURE IMMUNOLOGY
Volume 16, Issue 10, Pages 1014-1024Publisher
NATURE PORTFOLIO
DOI: 10.1038/ni.3273
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Japan Agency for Medical Research and Development CREST
- Cancer Research Switzerland [KFS-3234-08-2013]
- Worldwide Cancer Research [14-1033]
- University of Zurich
- Baugarten Foundation
- Sobek Foundation
- Fondation Acteria
- Swiss Vaccine Research Institute
- Swiss National Science Foundation [310030_143979, CRSII3_136241]
- Grants-in-Aid for Scientific Research [15H01380, 15K18530, 25111001, 15K14951, 26713005, 26111514] Funding Source: KAKEN
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Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond autophagy. In this Review, we introduce advances in the knowledge of the roles of autophagy and its components in immunity, including innate immunity, inflammatory responses and adaptive immunity.
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