Journal
NATURE IMMUNOLOGY
Volume 16, Issue 12, Pages 1282-1291Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3299
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Funding
- US National Institutes of Health [AI-28697, K12 HD052954, K12 HD034610, P01HL073104, T32HL066992, T32 HL086345]
- UCLA AIDS Institute
- UCLA Council of Bioscience Resources
- St. Baldrick's Foundation
- Nautica Foundation
- Tower Cancer Research Foundation
- Couples Against Leukemia Foundation
- Joseph Drown Foundation
- UCLA Broad Stem Cell Research Center
- California Institute for Regenerative Medicine [TG2-01169]
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To elucidate the transcriptional 'landscape' that regulates human lymphoid commitment during postnatal life, we used RNA sequencing to assemble the long non-coding transcriptome across human bone marrow and thymic progenitor cells spanning the earliest stages of B lymphoid and T lymphoid specification. Over 3,000 genes encoding previously unknown long non-coding RNAs (IncRNAs) were revealed through the analysis of these rare populations. Lymphoid commitment was characterized by IncRNA expression patterns that were highly stage specific and were more lineage specific than those of protein-coding genes. Protein-coding genes co-expressed with neighboring IncRNA genes showed enrichment for ontologies related to lymphoid differentiation. The exquisite cell-type specificity of global IncRNA expression patterns independently revealed new developmental relationships among the earliest progenitor cells in the human bone marrow and thymus.
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