Journal
NATURE IMMUNOLOGY
Volume 16, Issue 9, Pages 898-900Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3255
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Paneth cell dysfunction has been linked to Crohn's disease. Nod2 and LRRK2, two genetic susceptibility factors for this disease, are now shown to have a role in regulating the sorting of lysozyme in Paneth cells and its secretion into the crypt space and, ultimately, in maintenance of the intestinal barrier.
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