Journal
JOURNAL OF APPLIED PHYSIOLOGY
Volume 116, Issue 9, Pages 1133-1141Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.01242.2013
Keywords
anaerobic exercise; gastric motility; metabolic acidosis; sodium bicarbonate; swimming
Categories
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
- Conselho Nacional de Pesquisas
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
- Fundacao Cearense de Amparo a Pesquisa
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Physical exercise, mainly after vigorous activity, may induce gastrointestinal dysmotility whose mechanisms are still unknown. We hypothesized that physical exercise and ensuing lactate-related acidemia alter gastrointestinal motor behavior. In the present study, we evaluated the effects of short-term exercise on gastric emptying rate in awake rats subjected to 15-min swimming sessions against a load equivalent to 5% of their body weight. After 0, 10, or 20 min of exercise testing, the rats were gavage fed with 1.5 ml of a liquid test meal (0.5 mg/ml of phenol red in 5% glucose solution) and euthanized 10 min postprandially to measure fractional gastric dye recovery. In addition to inducing acidemia and increasing blood lactate levels, acute exercise increased (P < 0.05) gastric retention. Such a phenomenon presented a positive correlation (P < 0.001) between blood lactate levels and fractional gastric dye recovery. Gastric retention and other acidbase-related changes were all prevented by NaHCO3 pretreatment. Additionally, exercise enhanced (P < 0.05) the marker's progression through the small intestine. In anesthetized rats, exercise increased (P < 0.05) gastric volume, measured by a balloon catheter in a barostat system. Compared with sedentary control rats, acute exercise also inhibited (P < 0.05) the contractility of gastric fundus strips in vitro. In conclusion, acute exercise delayed the gastric emptying of a liquid test meal by interfering with the acid-base balance.
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