Journal
JOURNAL OF APPLIED PHYSIOLOGY
Volume 110, Issue 1, Pages 1-8Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.01061.2010
Keywords
carbon dioxide; control of breathing; pH
Categories
Funding
- National Institutes of Health [HL-28066, P01 HD-36379]
- Parker B. Francis Foundation
- CJ Foundation
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P01HD036379] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R37HL028066, R01HL028066] Funding Source: NIH RePORTER
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Nattie E. Julius H. Comroe, Jr., Distinguished Lecture: Central chemoreception: then ... and now. J Appl Physiol 110: 1-8, 2011. First published November 11, 2010; doi:10.1152/japplphysiol.01061.2010.-The 2010 Julius H. Comroe, Jr., Lecture of the American Physiological Society focuses on evolving ideas in chemoreception for CO2/pH in terms of what is sensed, where it is sensed, and how the sensed information is used physiologically. Chemoreception is viewed as involving neurons (and glia) at many sites within the hindbrain, including, but not limited to, the retrotrapezoid nucleus, the medullary raphe, the locus ceruleus, the nucleus tractus solitarius, the lateral hypothalamus (orexin neurons), and the caudal ventrolateral medulla. Central chemoreception also has an important nonadditive interaction with afferent information arising at the carotid body. While ventilation has been viewed as the primary output variable, it appears that airway resistance, arousal, and blood pressure can also be significantly affected. Emphasis is placed on the importance of data derived from studies performed in the absence of anesthesia.
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