Journal
NATURE GENETICS
Volume 47, Issue 7, Pages 784-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.3309
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Funding
- Energy Biosciences Institute
- Fred Dickinson Chair
- National Science Foundation Graduate Research Fellowship [DGE-0914548]
- Gordon and Betty Moore Foundation Fellowship from the Life Sciences Research Foundation
- National Science Foundation Plant Genome Research Program [0922661, 1237880]
- Agriculture and Food Research Initiative competitive grant of the US Department of Agriculture National Institute of Food and Agriculture [2015-67013-22823]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0922661, 1237880] Funding Source: National Science Foundation
- Grants-in-Aid for Scientific Research [15K21750] Funding Source: KAKEN
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Shoot meristems of plants are composed of stem cells that are continuously replenished through a classical feedback circuit involving the homeobox WUSCHEL (WUS) gene and the CLAVATA (CLV) gene signaling pathway. In CLV signaling, the CLV1 receptor complex is bound by CLV3, a secreted peptide modified with sugars. However, the pathway responsible for modifying CLV3 and its relevance for CLV signaling are unknown. Here we show that tomato inflorescence branching mutants with extra flower and fruit organs due to enlarged meristems are defective in arabinosyltransferase genes. The most extreme mutant is disrupted in a hydroxyproline O-arabinosyltransferase and can be rescued with arabinosylated CLV3. Weaker mutants are defective in arabinosyltransferases that extend arabinose chains, indicating that CLV3 must be fully arabinosylated to maintain meristem size. Finally, we show that a mutation in CLV3 increased fruit size during domestication. Our findings uncover a new layer of complexity in the control of plant stem cell proliferation.
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