Journal
NATURE GENETICS
Volume 47, Issue 7, Pages 696-698Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.3344
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Funding
- NICHD NIH HHS [R01 HD041012] Funding Source: Medline
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Crossing over, or reciprocal recombination, is essential for accurate segregation of homologous chromosomes at the first meiotic division, resulting in gametes containing the correct chromosome number. A new study in human oocytes analyzes the genome-wide recombination and segregation patterns in all the products of female meiosis, providing experimental support for existing theories about the origin of human aneuploidies and highlighting a novel reverse segregation mechanism of chromosome segregation during meiosis.
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