Journal
NATURE GENETICS
Volume 47, Issue 5, Pages 427-428Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.3290
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- Medical Research Council [MR/K011332/1] Funding Source: researchfish
- Medical Research Council [MR/K011332/1] Funding Source: Medline
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A hallmark of CpG islands is their unmethylated state, and determining how DNA methylation can invade these elements is therefore important for understanding developmental gene regulation and disease. A new study shows that FBXL10, a protein commonly altered by mutation in leukemia, is part of a mechanism that blocks methylation of CpG islands.
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