Journal
NATURE CHEMICAL BIOLOGY
Volume 11, Issue 1, Pages 9-15Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.1712
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Funding
- US National Institutes of Health [R01CA123067, 5T32HL076139-10]
- NATIONAL CANCER INSTITUTE [R01CA123067] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL076139] Funding Source: NIH RePORTER
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Mitochondria have a well-recognized role in the production of ATP and the intermediates needed for macromolecule biosynthesis, such as nucleotides. Mitochondria also participate in the activation of signaling pathways. Overall, accumulating evidence now suggests that mitochondrial bioenergetics, biosynthesis and signaling are required for tumorigenesis. Thus, emerging studies have begun to demonstrate that mitochondrial metabolism is potentially a fruitful arena for cancer therapy. In this Perspective, we highlight recent developments in targeting mitochondrial metabolism for the treatment of cancer. npg (C) 2015 Nature America, Inc. All rights reserved.
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