Journal
NATURE CHEMICAL BIOLOGY
Volume 11, Issue 6, Pages 387-397Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.1809
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Categories
Funding
- CQDM/OCE Explore Program
- Ontario Genomics Institute
- Canadian Cystic Fibrosis Foundation
- Canadian Cancer Society
- Pancreatic Cancer Canada
- University Health Network
- UK Medical Research Council [MC_EX_G0800785]
- Biotechnology and Biological Sciences Research Council New Investigator Award [BB/JO/5581/1]
- EC-Marie Curie International Incoming Fellowship (FP7-PEOPLE-IIF)
- Biotechnology and Biological Sciences Research Council [BB/J015881/1] Funding Source: researchfish
- Medical Research Council [MC_EX_G0800785] Funding Source: researchfish
- BBSRC [BB/J015881/1] Funding Source: UKRI
- MRC [MC_EX_G0800785] Funding Source: UKRI
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Research in signal transduction aims to identify the functions of different signaling pathways in physiological and pathological states. Traditional techniques using biochemical, genetic or cell biological approaches have made important contributions to our understanding of cellular signaling. However, the single-gene approach does not take into account the full complexity of cell signaling. With the availability of omics techniques, great progress has been made in understanding signaling networks. Omics approaches can be classified into two categories: 'molecular profiling', including genomic, proteomic, post-translational modification and interactome profiling; and 'molecular perturbation', including genetic and functional perturbations.
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