Journal
NATURE CHEMICAL BIOLOGY
Volume 11, Issue 11, Pages 834-U36Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1910
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Funding
- US National Institutes of Health [R01 AG033542, TL1 AG032116]
- Ellison Medical Foundation [AG-SS-2288-09]
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Mitochondrial electron transport drives ATP synthesis but also generates reactive oxygen species, which are both cellular signals and damaging oxidants. Superoxide production by respiratory complex III is implicated in diverse signaling events and pathologies, but its role remains controversial. Using high-throughput screening, we identified compounds that selectively eliminate superoxide production by complex III without altering oxidative phosphorylation; they modulate retrograde signaling including cellular responses to hypoxic and oxidative stress.
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