Journal
NATURE CHEMICAL BIOLOGY
Volume 11, Issue 8, Pages 555-U40Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.1848
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Funding
- Cancer Research UK [C14303/A17197]
- Wellcome Trust [WT099232, WT095645/Z/11/Z]
- Biotechnology and Biological Sciences Research Council UK [BB/K010867/1]
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000H112, BBS/E/B/000C0402] Funding Source: researchfish
- Cancer Research UK [12488, 6934] Funding Source: researchfish
- Wellcome Trust [099232/Z/12/Z] Funding Source: researchfish
- BBSRC [BBS/E/B/0000H112, BBS/E/B/000C0402] Funding Source: UKRI
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5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable isotope labeling in vivo, we show that 5fC can be a stable DNA modification. These results suggest that 5fC has functional roles in DNA that go beyond being a demethylation intermediate.
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