Journal
NATURE CHEMICAL BIOLOGY
Volume 11, Issue 3, Pages 195-U178Publisher
NATURE PORTFOLIO
DOI: 10.1038/nchembio.1734
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Funding
- Deutsche Forschungsgemeinschaft [DFG SU239/11-1, SU 18-1]
- Cluster of Excellence 'Unifying Concepts in Catalysis (UniCat)' (DFG)
- Agence Nationale de la Recherche [ANR-09-BLAN-0413-01]
- Agence Nationale de la Recherche (ANR) [ANR-09-BLAN-0413] Funding Source: Agence Nationale de la Recherche (ANR)
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Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids. In vitro studies provide further insights into the biosynthetic machinery of albicidin. These findings will enable structural investigations on the inhibition mechanism of albicidin and its assessment as a highly effective antibacterial drug.
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